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Laboratory：Akiruno

○BRCA1/2 gene testing (prostate cancer)

CODE：0R629 6

  • TEST NAME SPECIMEN
    REQUIREMENT
    （ｍL）     CONTAINER CAP COLOR STORE
    TEMPERATURE
    (STABILITY)     TURNAROUND
    TIME (DAY)     METHODOLOGY REFERENCE RANGE
    (UNIT)
  • Ethics recommission
    BRCA1/2 gene testing (prostate cancer)
    Blood (EDTA-2K added)
    7.0
    PNM Room temperature
     10-18 PCR and Sanger sequencing

    PCR (Polymerase chain reaction)
    A method for exponentially amplifying the target DNA region by using the fact that DNA dissociates from double-stranded DNA to single-stranded DNA by heating and returns to double-stranded DNA by cooling, binding the target primer to single-stranded DNA as a template, and repeatedly performing DNA synthesis by the transcription reaction of DNA polymerase.
    Sanger sequencing
    This method uses DNA polymerase, a DNA replication enzyme, to synthesize DNA fragments whose ends correspond to specific bases, and currently uses dideoxynucleotides labeled with four different fluorescent dyes in the elongation reaction. Sequences are determined by using a capillary electrophoresis system to detect the type of fluorescent dye of dye-terminator and the length of DNA fragments, incorporated randomly in the elongation reaction from a single primer that binds specifically to the template DNA.

COMMENT


This test is intended for prostate carcinoma. Avoid freezing. Please be sure to specify you sex when making your request. Please avoid duplicate requests of other items.
With this testing method, the affects of contamination will be greater, so please be careful when collecting and handling the specimen. The number of days required may vary depending on the measurement and analytical situations.
●About BRCA1/2 Gene Test
It is a companion diagnosis used to provide healthcare professionals with clinically significant variant classification of patients and to assist in determining the indication for olaparib.
●About Submission
・When requesting this test, please obtain your Myriad account ID in advance.
・Please be sure to collect your blood specimen into a dedicated blood collection tube and submit it on the same day.
・Please note in advanve that specimens cannot be returned.
●Notes for Contracting
If any of the following apply to you, you cannot request this item.
・Other than those with breast, ovarian, pancreatic, or prostate carcinoma *Cannot be used to diagnose asymptomatic cases or blood relatives.
・Those with a history of allogeneic bone marrow transplantation
・Those with a history of hematopoietic tumors (CLL, MDS, myeloproliferative disorders)
・Those with hematopoietic tumors (ALL, AML, CML) not in remission

●When Requesting with This Test
When requesting with this test, please read the following information and use the dedicated request form.
1. To protect personal information, please anonymize the name of the examinee and enter it in the “Anonymous code” field.
2. Please check the box to confirm that the purpose and limitations of the test and the significance of the BRCA1/2 gene have been explained and that the examinee's consent in writing has been obtained.
3. Please use an anonymous code for any inquiries about the test results.
4. A part of your anonymized personal information may be

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