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Laboratory：Akiruno

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TEST NAME	SPECIMEN REQUIREMENT （ｍL）	CONTAINER	CAP COLOR	STORE TEMPERATURE (STABILITY)	TURNAROUND TIME (DAY)	METHODOLOGY	REFERENCE RANGE (UNIT)	BLOOD COLLECTION TIME
Acetaminophen	Serum 0.4	S7P ↓ A00			2-8	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	Toxic range 200.1 or higher (4 hours) 100.1 or higher (8 hours) 50.1 or higher (12 hours) (μg/mL)
Theophylline	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	10.0-20.0(μg/mL)	See below
Theophylline	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	10.0-20.0(μg/mL)	See below
Salicylic acid	Serum 0.4	S7P ↓ A00			2-4	Enzymatic method Enzymatic method This technique is based on the same assay principle as the colorimetry. Analytes are specifically measured using enzymatic reactions.	100-250 (μg/mL) for anti-inflammatory effect	Immediately before next administration (Trough concentration)
Heparin	Plasma 0.3	PC2 ↓ A00		（1 month）	4-8	Chromogenic synthetic substrate method Chromogenic synthetic substrate method A method in which heparin is added to form an AT-III-heparin complex, and its ability to inactivate thrombin is measured using a chromogenic synthetic substrate for thrombin.	(IU/mL)
Methotrexate	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	Hazardous limit concentration 24-hour value 10 or more 48-hour value 1 or more 72-hour value 0.1 or more (μmol/L)	24, 48, 72 hours during methotrexate/leucovorin rescue therapy
Methotrexate	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	Hazardous limit concentration 24-hour value 10 or more 48-hour value 1 or more 72-hour value 0.1 or more (μmol/L)	24, 48, 72 hours during methotrexate/leucovorin rescue therapy
Imatinib	Plasma 0.3	PN2,PN5 ↓ A00		（21 days）	3-16	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(ng/mL)	24 hours ± 2 hours after taking (Trough concentration)
Ribavirin（Suspended beyond orders placed 11-30-2017）	Serum 0.5	S7P ↓ A00			3-5	HPLC HPLC (High performance liquid chromatography) Liquid chromatography Method for high-speed and high-precision separation using liquid chromatography employing a mobile phase with liquid and employing high-density packing columns and high-pressure pumps	(ng/mL)