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Laboratory：Akiruno

○BRCA1/2 gene test (ovarian cancer)

CODE：0R221 8

  • TEST NAME SPECIMEN
    REQUIREMENT
    （ｍL）     CONTAINER CAP COLOR STORE
    TEMPERATURE
    (STABILITY)     TURNAROUND
    TIME (DAY)     METHODOLOGY REFERENCE RANGE
    (UNIT)
  • Ethics recommission
    BRCA1/2 gene test (ovarian cancer)
    Blood (EDTA-2K added)
    7.0
    PNM Room temperature
     10-18 PCR and Sanger sequencing

    PCR (Polymerase chain reaction)
    A method for exponentially amplifying the target DNA region by using the fact that DNA dissociates from double-stranded DNA to single-stranded DNA by heating and returns to double-stranded DNA by cooling, binding the target primer to single-stranded DNA as a template, and repeatedly performing DNA synthesis by the transcription reaction of DNA polymerase.
    Sanger sequencing
    This method uses DNA polymerase, a DNA replication enzyme, to synthesize DNA fragments whose ends correspond to specific bases, and currently uses dideoxynucleotides labeled with four different fluorescent dyes in the elongation reaction. Sequences are determined by using a capillary electrophoresis system to detect the type of fluorescent dye of dye-terminator and the length of DNA fragments, incorporated randomly in the elongation reaction from a single primer that binds specifically to the template DNA.

COMMENT


This test targets ovarian cancer.
Avoid cryopreservation. Please be sure to specify your gender when making your request. Please avoid duplicate requests with other items. This testing method can be affected by contamination, so please be careful when handling the specimen. The number of days required may vary depending on the measurement and analysis situation.
●What is BRCA1/2 genetic testing?
It is a companion diagnostic used to provide medical professionals with a clinically meaningful variant classification of patients and to assist in determining suitability for Olaparib.
●About submission
・When requesting this test, please obtain your Myriad account ID in advance.
・Please be sure to collect blood in a special blood collection tube and submit it on the same day.
・Samples cannot be returned thank you for your understanding.
●Precautions for consignment
Persons who fall under the following conditions cannot request this item.
・Persons other than breast cancer and ovarian cancer *Cannot be used to diagnose asymptomatic or blood relatives
・Persons with a history of allogeneic bone marrow transplantation
・Hematopoietic tumors (CLL, MDS, bone marrow proliferation) Persons who have developed a sexual disease
・Persons whose hematopoietic tumors (ALL, AML, CML) are not in remission

●When requesting this test
Please request this test. When making a request, please read the information below and use the special request form.
1. To protect personal information, please anonymize the test subject's name and enter it in the “anonymous code” field.
2. To confirm that the purpose and limitations of the test and the significance of the BRCA1/2 genes have been explained, and that written consent has been obtained from the test subject.
3. For inquiries about test results, please use an anonymous code.
4. Some of the anonymized personal information will be used by Myriad Genetic Laboratories, Inc. (USA

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