TEST DIRECTORY

COMMENT

When requesting this test, please submit one HE-stained slide along with the unstained specimen slide.
The percentage of tumor cells required for the test is at least 20%. Refer to the following for the notes on submitting unstained specimen slides.
Avoid duplicate requests for other items. Be sure to specify the sex of the applicant when requesting the test.
Since this test method is more affected by contamination, be careful when collecting specimens. The number of days required may vary depending on the measurement and analysis situation.

● What is myChoice Diagnostic System? It is a companion diagnostic used to detect Homologous Recombination Deficiency (HRD) by assessing genomic instability status (GIS) and BRCA1/2 gene mutations in genomic DNA extracted from tumor tissue and to assist in determining the indication for a specific drug.

● About submission of myChoice diagnostic system
When requesting this test, obtain a Myriad account ID in advance.
・Please understand in advance that specimens cannot be returned.

● When submitting a request for the myChoice Diagnostic System
Please read the following information and use the dedicated request form when submitting a request for this test.

1. Check to confirm that the purpose and limitations of the test have been explained to the patient and that the patient's written consent has been obtained.
2. Some of the anonymized personal information may be used by Myriad Genetic Laboratories, Inc. (USA), the measurement and analysis organization for this test, to ensure the quality of BRCA1/2 genetic test.
3. Please check the notices from related academic societies.
● How to request myChoice Diagnostic System
1. Access the dedicated request entry site.
2. After logging in, enter the necessary request information.
3. After completing the entry, print out the request form and submit it with the specimen.
* Internet connection is required.

● Unstained specimen slides
The collected tissue should be immediately immersed in 10% neutral buffered formalin solution and fixed (recommended fixation time: 6-72 hours). When submitting specimens, make serial sections of the specified thickness from formalin-fixed, paraffin-embedded (FFPE) blocks prepared within the past 3 years, if possible. Be careful to avoid contamination by changing the blade of the microtome for each specimen when thin sectioning.Additionally, note that since nucleic acids are fragmented by formalin fixation of tissues, analysis may not be possible depending on the type and composition of the fixation solution, fixation time, and storage conditions of the specimens after fixation.

supplementary information

2023/09/08→梅津

2017/09/21

2023/09/08

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2020/11/26

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2021/04/07→大原

2021/04/07

2021/04/07

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