Urinary styrene metabolites

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biochemical test
toxins, industrial medicine related metabolites
Urinary styrene metabolites

Laboratory：Akiruno

○Urinary styrene metabolites

CODE：08480 0

TEST NAME SPECIMEN
REQUIREMENT
（ｍL） CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY REFERENCE RANGE
(UNIT)
Urinary styrene metabolites
Partial urine
1.8
U00
（14 days）
4-14 HPLC
HPLC (High performance liquid chromatography)
High performance liquid chromatography
A method of liquid chromatography that uses a liquid as a mobile phase to achieve high speed and high precision separation using a densely packed column and a high pressure pump.
(g/L)

COMMENT

Collect urine at the end of the work on a weekend working day. Please note that urine needs to be excreted once 2 hours before collecting a sample.
The measured values are mandelic acid (MA), phenylglyoxylic acid (PGA) and the total value (MA+PGA).
Biological tolerance: 0.43 (g/L) or less. (Biological tolerance is a concentration at which almost all workers are judged to have no adverse health effects.)
The required number of days will vary depending on the number of requests.
Please see below.

CONTAINER

U00 旧容器記号 Y

尿用容器

貯蔵方法：室温

supplementary information

産業医学 (有機溶剤、鉛) 関連検査

産業医学関連検査は、有機溶剤作業者、鉛作業者を対象として、体内に有機溶剤や鉛がどの程度取り込まれているかを定期的にチェックすることを主な目的としているため、結果の評価については、正常・異常の鑑別を目的としたものではなく、作業環境を含めた総合的な判断が必要とされています。
また、労働安全衛生法に基づく各中毒予防規則では、各健康診断結果報告書を、所轄の労働基準監督署長に提出することが定められています。

有機溶剤、鉛関連検査結果分布表

有機溶剤等健康診断結果報告書 (有機溶剤中毒予防規則、様式第3号の2)
鉛健康診断結果報告書 (鉛中毒予防規則、様式第3号) より

対象物質	測定項目	単位	分布
対象物質	測定項目	単位	1	2	3
トルエン	**　尿中馬尿酸	g/L	1以下	1超　2.5以下	2.5超
キシレン	**　尿中メチル馬尿酸	g/L	0.5以下	0.5超　1.5以下	1.5超
1･1･1-トリクロルエタン	***　尿中総三塩化物	mg/L	10以下	10超　40以下	40超
1･1･1-トリクロルエタン	***　尿中トリクロル酢酸	mg/L	3以下	3超　10以下	10超
N･N-ジメチルホルムアミド	**　尿中N-メチルホルムアミド	mg/L	10以下	10超　40以下	40超
ノルマルヘキサン	**　尿中2,5-ヘキサンジオン	mg/L	2以下	2超　5以下	5超
鉛	血中鉛	μg/dL	20以下	20超　40以下	40超
鉛	*　尿中δ-アミノレブリン酸	mg/L	5以下	5超　10以下	10超
スチレン	***　尿中スチレン代謝物　※1	g/L	分布報告はいたしません。
トリクロルエチレン	***　尿中総三塩化物	mg/L	100以下	100超　300以下	300超
トリクロルエチレン	***　尿中トリクロル酢酸	mg/L	30以下	30超　100以下	100超
テトラクロルエチレン	***　尿中総三塩化物	mg/L	3以下	3超　10以下	10超
テトラクロルエチレン	***　尿中トリクロル酢酸	mg/L	3以下	3超　10以下	10超

※1：測定値は、マンデル酸とフェニルグリオキシル酸の合算値です。

2014年11月より、スチレン、トリクロルエチレン、テトラクロルエチレンは、有機溶剤中毒予防規則から特定化学物質障害予防規則の対象に位置づけられました。

検体取り扱い方法

*　遮光保存してください。
**　連続した作業日の初日を除いた作業終了時に採尿してください。ただし、採尿2時間前に一度排尿してください。
***　週末の作業日の作業終了時に採尿してください。ただし、採尿2時間前に一度排尿してください。

Occupational Medicine (Organic solvents, Lead) Related Test

The occupational medicine-related test is mainly intended to regularly check the level of organic solvents or lead intake in the living body for organic solvents and lead workers. Therefore, the evaluation of the results requires a comprehensive judgment including the work environment, rather than the one intended to differentiate normality and abnormality.
In addition, each Regulation on Prevention of Poisoning based on the Industrial Safety and Health Act stipulates that each report of the results of a medical examination shall be submitted to the Chief of the Labour Standard Inspection Offices in charge.

From the Report of the Results of a Medical Examination for Organic Solvents (Regulation on Prevention of Organic Solvent Poisoning, Form No. 3-2), the Report of the Results of a Medical Examination for Lead (Regulation on Prevention of Lead Poisoning, Form No. 3)

Distribution Table for the Organic Solvents, Lead-Related Test Results

Target Substance	Measurement Item	Unit	Distribution
Target Substance	Measurement Item	Unit	1	2	3
Toluene	** Urinary hippuric acid	g/L	1 or less	More than 1, 2.5 or less	More than 2.5
Xylene	** Urinary methylhippuric acid	g/L	0.5 or less	More than 0.5, 1.5 or less	More than 1.5
1,1,1-Trichloroethane	*** Urinary total trichloride	mg/L	10 or less	More than 10, 40 or less	More than 40
1,1,1-Trichloroethane	*** Urinary trichloroacetic acid	mg/L	3 or less	More than 3, 10 or less	More than 10
N,N-Dimethylformamide	** Urinary N-methylformamide	mg/L	10 or less	More than 10, 40 or less	More than 40
Normal hexane	** Urinary 2,5-hexanedione	mg/L	2 or less	More than 2, 5 or less	More than 5
Lead	Blood lead	μg/dL	20 or less	More than 20, 40 or less	More than 40
Lead	* Urinary delta-aminolevulinic acid	mg/L	5 or less	More than 5, 10 or less	More than 10
Styrene	*** Urinary styrene metabolite *1	g/L	We will not report the distribution.
Trichloroethylene	*** Urinary total trichloride	mg/L	100 or less	More than 100, 300 or less	More than 300
Trichloroethylene	*** Urinary trichloroacetic acid	mg/L	30 or less	More than 30, 100 or less	More than 100
Tetrachloroethylene	*** Urinary total trichloride	mg/L	3 or less	More than 3, 10 or less	More than 10
Tetrachloroethylene	*** Urinary trichloroacetic acid	mg/L	3 or less	More than 3, 10 or less	More than 10

*1: Measurement values are the sum of mandelic acid and phenylglyoxylic acid.

Since November 2014, styrene, trichloroethylene, and tetrachloroethylene have been positioned from the subjects of the Regulation on Prevention of Organic Solvent Poisoning to those of the Regulation on Prevention of Hazards due to Specified Chemical Substances.

Specimen Handling

* Store in light-resistant containers.
** Sample urine at the end of work except for the first day of consecutive working days. However, urinate once 2 hours before urine sampling.
*** Sample urine at the end of work on weekend working days. However, urinate once 2 hours before urine sampling.

TEST DIRECTORY