![Room temperature [Materials: formalin-fixed tissues (Paraffin blocks or unstained slides are also available.)]](../../common/otherdata-images/en_202-01-01.gif)
Laboratory：Akiruno
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- pathological test
- *enzyme antibody staining
- Keratin (wide range)
Laboratory：Akiruno
○Keratin (wide range)
CODE：05925 9
-
TEST NAME
SPECIMEN SUBMISSION
SPECIMEN
REQUIREMENT
CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY -
Keratin (wide range)
Formalin-fixed tissue (paraffin block/unstained specimen slides are also available) VP0
*5-8
TEST NAME | SPECIMEN SUBMISSION | SPECIMEN |
|---|---|---|
Keratin (wide range)
| Formalin-fixed tissue (paraffin block/unstained specimen slides are also available) |
|
CONTAINER | CAP COLOR | STORE |
|---|---|---|
|
TURNAROUND | METHODOLOGY |
|---|---|
*5-8 |
|
COMMENT
*Required number of days
・If degreasing and deashing are required, the required number of days will be 7 to 12 days.
・If enzyme antibody staining is required, it will take approximately 2 weeks.
・If fluorescent antibodies are required, the required time will be 2 to 3 weeks.
・If a bone marrow image is required, it will take approximately 2 weeks.
・Organs that require diagnosis by a specialist (skin, liver, bone marrow, heart, etc.) require 7 to 12 days.
・Surgical materials (when cutting out more than 5 blocks) will take 2 to 3 weeks.
・ In the case of special requests, if there is a large number of requests (approximately 20 or more depending on the processing content), the required number of days will be longer than usual, so please contact our sales staff in advance.
About the pathology container (VP0)
Please fill the pathology container (VP0) with 20% formalin solution, fix the tissue, and submit.
If the tissue is too large to fit into the pathology container (VP0), please fix it thoroughly and submit it in a Histopack (extra large, large, medium, small).
CONTAINER
VP0 Previous container symbol u5
Pathology container
Fill the container with 10-20% formalin solution.
Storage method: Room temperature
supplementary information
List of enzyme antibody staining
| CODE | TEST NAME | ANTIGEN DISTRIBUTION | CLINICAL SIGNIFICANCE |
|---|---|---|---|
| TUMOR-RELATED | |||
05901 5
|
CEA | Normal colonic mucosa, fetal gastric mucosa (pyloric region), ducts of the salivary gland from fetuses | Many adenocarcinomas, some squamous cell carcinomas, some carcinoids, medullary carcinoma of thyroid, some small cell lung cancers |
05902 4
|
AFP (α-fetoprotein) | Hepatocytes/yolk sac/intestinal epithelium of the fetal period | Hepatocellular carcinoma, yolk sac tumor, some stomach cancers, immature teratoma, pancreatoblastoma |
05906 0
|
NSE | Nerve cells, nerve fiber, (some) endocrine cells, adrenomedullary cells | Neuroendocrine tumor, melanoma, myogenic tumor |
05907 9
|
HCG | Placental villous syncytiotrophoblast | Choriocarcinoma, some adenocarcinomas including stomach cancer, carcinoid (α-subunit), germinoma, large cell lung cancer, malignant islet-cell carcinoma |
| IMMUNOGLOBULINS AND COMPLEMENT | |||
05908 8
|
IgG | B lymphocytes, plasma cells | Plasmacytoma, myeloma, primary glomerular disease, glomerular disease associated with other diseases |
05909 7
|
IgA | ||
05910 5
|
IgM | ||
05911 4
|
κ chain | Plasmacytoma | |
05912 3
|
λ chain | ||
05913 2
|
C1q | Primary glomerular disease, glomerular disease associated with other diseases | |
05914 1
|
C3 | ||
05916 9
|
Fibrinogen | ||
| TISSUE MARKERS | |||
05923 1
|
Epithelial membrane antigen (EMA) | Many glandular epithelia/ductular epithelia, some mesothelia | Many adenocarcinomas, squamous cell carcinoma, (some) mesotheliomas, synovial sarcoma, chordoma |
05925 9
|
Keratin (wide range) | Almost all epithelial cells, mesothelial cells | Squamous cell carcinoma, some adenocarcinomas, mesothelioma, adenomatoid tumor, small cell lung cancer, medullary carcinoma of thyroid, carcinoid, epithelioid sarcoma, synovial sarcoma, chordoma, thymoma, choroid plexus papilloma |
05926 8
|
High molecular keratin (34βE12) | Squamous cells | Squamous cell carcinoma |
05928 6
|
Vimentin | Mesenchymal cells, epithelial cells in the mitotic phase, tubular epithelium of fetal kidney | Mesenchymal tumor, some cancers (e.g., Grawitz tumor, thyroid cancer), (some) undifferentiated carcinomas |
05929 5
|
Myoglobin | Skeletal muscle, thymic medullary myoid cells | Rhabdomyosarcoma, tumor components indicating differentiation to striated muscle |
05930 3
|
Desmin | Smooth muscle cells, skeletal muscle cells | Muscular tumor |
05931 2
|
S100 protein | Astrocytes, Schwann cells, satelite cells (neuromuscular cells), chondrocytes, fat cells, T-zone histiocytes, Langerhans cells (skin), myoepithelial cells | Glioma, schwannoma, nevus, melanoma, paraganglioma (satelite cells), (some) fibrous histiocytomas, histiocytosis X, chondrosarcoma, chordoma, liposarcoma, mixed tumor of salivary gland |
05932 1
|
Glial fibrillary acidic protein (GFAP) | Astrocytes, ependymal cells | Glioma, ependymoma, medulloblastoma, choroid plexus papilloma |
05933 0
|
Neurofilament (NF) | Nerve cells, nerve fiber, adrenomedullary cells, (some) endocrine cells | Neuroblastoma, pheochromocytoma, carcinoid, small cell lung cancer, medullary carcinoma of thyroid, pineocytoma |
05934 9
|
Factor VIII-related antigen | Vascular endothelium, (some) lymphatic endothelia, megakaryocytes | Angioma, Kaposi sarcoma |
05935 8
|
Prostate-specific antigen (PA) | Prostate epithelium | Prostate cancer |
05936 7
|
Prostatic acid phosphatase (PSAP) | Prostate epithelium, some endocrine cells | Prostate cancer, some endocrine gland tumors |
05937 6
|
Lysozyme | Paneth cells, pyloric gland, salivary gland, bronchial gland, bile duct accessory gland, tubular epithelium, granulocytes, macrophages | Adenocarcinoma derived from the gastric/pulmonary/biliary system, salivary gland tumor, histiocytic tumor |
| HORMONES (PANCREAS/GUT) | |||
05942 0
|
Glucagon | A-cells of the Langerhans islets | Langerhans adenoma, ectopic hormone-producing tumor |
05943 9
|
Gastrin | G-cells in the stomach/intestines | |
05944 8
|
Somatostatin | D-cells of the Langerhans islets, D-cells in the stomach/intestines | |
05947 5
|
Serotonin | Normal endocrine cells | Carcinoid |
| HORMONES (PLACENTAL FUNCTION) | |||
05950 1
|
Placental alkaline phosphatase (PLAP) | Placental villous syncytiotrophoblast, reserve cells of cervical cancer, endometrial lining epithelium | Seminoma, some adenocarcinomas, cervical cancer (exceptional) |
| HORMONES (THYROID GLAND/PARATHYROID FUNCTION) | |||
05886 3
|
Calcitonin | Thyroid C cells, bronchial K cells | Medullary carcinoma of thyroid, small-cell lung cancer, bronchial carcinoid, Langerhans tumor (in some cases) |
05887 2
|
Parathyroid hormone (PTH) | Parathyroid cells | Parathyroid cancer, ectopic hormone-producing tumor |
| HORMONES (PITUITARY FUNCTION) | |||
05890 8
|
Thyroid stimulating hormone (TSH) | Anterior pituitary gland | Pituitary adenoma, ectopic hormone-producing tumor |
05891 7
|
Growth hormone (GH) | ||
05892 6
|
Luteinizing hormone (LH) | ||
05895 3
|
Prolactin (PRL) | ||
05896 2
|
Antidiuretic hormone (ADH) | Posterior pituitary gland | |
| LYMPHOCYTE-RELATED | |||
05917 8
|
Leukocyte common antigen (LCA) | Lymphocytes, histiocytes (in some cases) | Malignant lymphoma, plasmacytoma, chloroma |
05918 7
|
T lymphocytes (UCHL-1) | T lymphocytes, polymorphonuclear leukocyte, histiocytes (in some cases) | Malignant T lymphoma |
05920 4
|
B lymphocytes (L-26) | B lymphocytes | Malignant B lymphoma |
05899 9
|
Leu M1 | Polymorphonuclear leukocyte, monocytes, activated T lymphocytes, normal epithelial cells, proximal tubular epithelium | Hodgkin lymphoma |
