Laboratory：Akiruno
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- Amiodarone
Laboratory：Akiruno
○Amiodarone
CODE：02738 0
-
TEST NAME
SPECIMEN
REQUIREMENT
（ｍL） CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY REFERENCE RANGE
(UNIT) BLOOD COLLECTION TIME -
Amiodarone
Plasma
0.3
PH5
↓
A00
3-5 LC/MS/MS(ng/mL) Immediately before next administration (Trough concentration)LC/MS/MS (Liquid chromatography tandem mass spectrometry)
Liquid chromatography tandem quadrupole mass spectrometry
Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.
COMMENT
Amiodarone effective blood concentration: 500 to 1000 ng/mL (200 mg/day administration, steady state, trough value) Desethylamiodarone/Amiodarone = 0.8 (steady state). Ancaron
Points to note concerning blood collecting containers
Avoid using a container with a serum separating agent. It may effect the results on the drug tests.
Points to note concerning the blood collecting time
1. The blood collecting time is for TDM (therapeutic drug monitoring).
2. In repetitive administration, collect a blood sample after a steady state is achieved.
3. When poisoning is developed, the peak concentration also needs to be measured.
4. The blood collecting time shows the standard time: a patient's condition should be taken into account in collecting a blood sample.
After drawing blood into a container shown in the below image, mix well, and separate plasma.
Refrigerate the plasma samples.
CONTAINER
PH5 旧容器記号 G 12
ヘパリン入り (真空採血量5mL)
内容：ヘパリンNa 65IU
貯蔵方法：室温
有効期間：製造から2年
A00 旧容器記号 X
ポリスピッツ
貯蔵方法：室温
