Lung Cancer Oncomine DxTT Multi 7 Gene CDx FF

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gene-related test
genetic tests for malignant tumor (solid tumor)
Lung Cancer Oncomine DxTT Multi 7 Gene CDx FF

Laboratory：Akiruno

○Lung Cancer Oncomine DxTT Multi 7 Gene CDx FF

CODE：00W85 5

TEST NAME SPECIMEN
REQUIREMENT
（ｍL） CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY REFERENCE RANGE
(UNIT)
Lung Cancer Oncomine DxTT Multi 7 Gene CDx FF
tissue
100mg
ARR
6-9 Next Generation Sequencing (NGS)
A method that uses a next-generation sequencer to simultaneously determine the base sequences of a huge number of DNA fragments.

COMMENT

The purpose of this service is to analyze BRAF gene V600E mutation, EGFR gene mutation, HER2 (ERBB2) gene mutation, ALK fusion gene, ROS1 fusion gene, RET fusion gene, and METex 14 skipping mutation with genomic DNA and RNA extracted from cancer tissue, and to assist in determining whether drugs listed in the separate table are suitable for non-small cell lung cancer patients.
Requests can be accepted from Monday to Friday.
Please submit materials after confirming that they contain tumor tissue. Please avoid duplicate requests for other items. This test method is subject to the effects of contamination. The interference will be greater, so please handle the samples with care when collecting them.
When requesting this test, please be sure to also request the nucleic acid extraction item (item code no: 0M9612).
*About materials other than tissue
Place the collected pleural fluid, alveolar lavage fluid, and bronchial brushing lavage fluid in the designated container (ARR) and centrifuge (760G (2000-3000rpm) x 10 minutes) at room temperature. Remove as much of the supernatant as possible, and be sure to freeze the sediment before submitting it.
*Points to note
Please process the sample immediately after collection. Note that if the cell count in the submitted sample is low, it may not be possible to perform the test.

CONTAINER

ARR 旧容器記号 r A

滅菌ポリスピッツ

貯蔵方法：室温

supplementary information

オンコマインDxTTマルチ検査における対象遺伝子変異等と関連する医薬品および適応がん腫

遺伝子変異等	がん腫	関連する医薬品
BRAF 遺伝子V600E変異	非小細胞肺癌	ダブラフェニブメシル酸塩及びトラメチニブジメチルスルホキシド付加物の併用投与
EGFR遺伝子変異 (エクソン20挿入変異を除く)		ゲフィチニブ、エルロチニブ塩酸塩、アファチニブマレイン酸塩、オシメルチニブメシル酸塩、ダコミチニブ水和物
EGFR遺伝子エクソン20挿入変異		アミバンタマブ (遺伝子組換え)
HER2 (ERBB2) 遺伝子変異		トラスツズマブデルクステカン (遺伝子組換え)
ALK融合遺伝子		クリゾチニブ、アレクチニブ塩酸塩、ブリグチニブ、ロルラチニブ
ROS1融合遺伝子		クリゾチニブ、エヌトレクチニブ
RET融合遺伝子		セルペルカチニブ
METex14 スキッピング変異		カプマチニブ塩酸塩水和物、テポチニブ塩酸塩水和物

TEST DIRECTORY