Laboratory：Akiruno
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- gene-related test
- genetic tests for malignant tumor (solid tumor)
- Lung cancer compact panel CDx（Suspended beyond orders placed 03-29-2024）
Laboratory：Akiruno
○Lung cancer compact panel CDx（Suspended beyond orders placed 03-29-2024）
CODE：00Q67 1
-
TEST NAME
SPECIMEN
REQUIREMENT
（ｍL） CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY REFERENCE RANGE
(UNIT) -
Lung cancer compact panel CDx（Suspended beyond orders placed 03-29-2024）
Unstained specimen slide
5-10 pieces 5μm
Z10
8-15 Next Generation Sequencing (NGS)A method that uses a next-generation sequencer to simultaneously determine the base sequences of a huge number of DNA fragments.
TEST NAME | SPECIMEN | CONTAINER |
|---|---|---|
|
Unstained specimen slide
|
CAP COLOR | STORE | TURNAROUND |
|---|---|---|
| 8-15 |
METHODOLOGY | REFERENCE RANGE |
|---|---|
Next Generation Sequencing (NGS) A method that uses a next-generation sequencer to simultaneously determine the base sequences of a huge number of DNA fragments. |
|
other material
COMMENT
The purpose of this study is to detect EGFR gene mutation, ALK fusion gene, ROS1 fusion gene, and MET ex14 skipping mutation using nucleic acids extracted from cancer tissues to determine the indication of drugs for non-small cell lung cancer.
The percentage of tumor cells required for testing is 10% or more. Please see below for notes on submitting unstained specimen slides. In addition, when submitting specimens, please follow the detailed information for specimen submission in the product pamphlet issued by DNA Chip Research Laboratories.
Please avoid duplicate requests with other items. Since this test method is more susceptible to contamination, please handle the specimens with care when collecting them.
※To request this inspection, an account registration application is required.
●When requesting this inspection
Please submit specimens according to the detailed information for specimen submission in the product pamphlet issued by the DNA Chip Research Institute.
Unstained specimen slides should be histopathologically evaluated to ensure that tumor cells are present in a proportion greater than that required for testing.
●About unstained specimen slides
The collected tissue should be immediately immersed in a 10% neutral buffered formalin solution for fixation (Recommended immobilization time is 6-48 hours). When submitting, please prepare serial sections of the specified thickness from formalin-fixed, paraffin-embedded (FFPE) blocks made within the last 3 years whenever possible. Please be careful to avoid contamination by changing the microtome blade for each specimen during thin sectioning. Additionally, please note that since nucleic acids are fragmented by formalin fixation of tissues, analysis may not be possible depending on the type and composition of the fixation solution, fixation time, and storage conditions of the specimens after fixation.
●About biopsy specimens
Please note that biopsy specimens are often m
CONTAINER
![[Object cases] Preparation (slide glass)](../../common/yoki-images/z10.jpg)
Z10 Previous container symbol t
[Object cases] Preparation (slide glass)
Storage method: Room temperature
supplementary information
Drugs related to target gene mutations, etc. and applicable cancer tumors
| Gene mutation, etc. | Carcinoma | Related Drugs |
|---|---|---|
| EGFR gene mutation | non-small cell lung cancer | Gefitinib, Erlotinib Hydrochloride, Afatinib Maleate, Osimertinib mesylate |
| ALK fusion gene | Crizotinib, Alectinib Hydrochloride, Brigatinib, | |
| ROS1 fusion gene | Crizotinib | |
| METex14 skipping mutation | Tepotinib hydrochloride hydrate |
