TEST DIRECTORY

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Laboratory：Akiruno

○MMR protein (IHC)

CODE：00M84 6

  • TEST NAME SPECIMEN SUBMISSION SPECIMEN
    REQUIREMENT
     CONTAINER CAP COLOR STORE
    TEMPERATURE
    (STABILITY)     TURNAROUND
    TIME (DAY)     METHODOLOGY
  • MMR protein (IHC)
    Unstained specimen slide 9 unstained slide specimens Z10 Room temperature
     5-10 Immunohistochemical staining method

COMMENT


・This test confirms the retention or loss of mismatch repair proteins MLH1, MSH2, PMS2, and MSH6 by immunohistochemical staining (IHC).
・The results of this test may cause suspicion of Lynch syndrome.
On the occasion of testing, ″Opinion ver.2 on the use of microsatellite instability tests for malignant tumors and immunohistochemical tests for mismatch repair proteins″, published by the Japanese Society for Hereditary Tumors, describes the following.
“When Lynch syndrome is suspected clinically or laboratory results reveal a dMMR tumor, the patient should be fully informed about Lynch syndrome. It is also desirable to provide appropriate genetic counseling and opportunities for genetic care, including referrals to other medical institutions when necessary.″
How to submit MMR protein (IHC)
1) Since the presence or absence of cancer cells may be unknown, please attach a copy of the pathology report at the time of the test request (however, this is not required if a general pathology test is performed at our company). If for some reason you are unable to attach the pathology report, please provide the name of the pathology diagnosis (histological type, etc.) and as much clinical information as possible in the request form.
2) Materials will be unstained specimen slides (prepared from formalin-fixed paraffin blocks) of solid tumors. Please use silane or other coating slides and after thinning, dry the slides overnight at approximately 40°C before submitting them.
3) Thinly slice the tissue to a thickness of 4 μm and attach it to the center of the tissue as much as possible.
4) If you request a paraffin block, please check with our sales staff for a delay in the time required for the preparation of unstained specimen slides.
5) 10% neutral buffered formalin is recommended for tissue fixation.

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