Laboratory：Akiruno
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- Aldosterone 〔CLEIA〕/renin concentration ratio
Laboratory：Akiruno
○Aldosterone 〔CLEIA〕/renin concentration ratio
CODE：00G06 8
-
TEST NAME
SPECIMEN
REQUIREMENT
（ｍL） CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY REFERENCE RANGE
(UNIT) -
Aldosterone 〔CLEIA〕/renin concentration ratio
Plasma
1.0
PN2,PN5
↓
A00
（21 days）
2-4 CLEIASee belowCLEIA (Chemiluminescent enzyme immunoassay)
Chemiluminescent enzyme immunoassay
After reacting the antigen with the immobilized antibody, the enzyme-labeled antibody is subjected to a secondary reaction with the antigen, and a chemiluminescent substrate is added. method to measure luminescence intensity.
COMMENT
The standard value is the cut-off value according to the "Primary Aldosteronism Treatment Guidelines 2021" of the Japan Endocrine Society.
"04609 1: Aldosterone [CLEIA]", "00G06 8: Aldosterone [CLEIA]/renin concentration ratio", "00E49 3: Aldosterone [CLEIA]/renin activity ratio" cannot be requested at the same time.
"06961 8: Renin concentration (ARC) [CLEIA]" and "00G06 8: Aldosterone [CLEIA]/renin concentration ratio" cannot be requested at the same time.
●Notes on aldosterone [CLEIA]/renin concentration ratio
・It is stated that blood collection is preferred to be conducted in the early morning, fasted, and in a resting position, but, that screening can be conducted in a sitting position at any time.
・When stored refrigerated, an increase in renin concentration will be observed.
Collect blood into the container shown below, mix well, and separate the plasma. Be sure to store plasma frozen.
CONTAINER
PN2 旧容器記号 C C3 4
EDTA-2Na入り (真空採血量2mL)
内容：EDTA-2Na 3.0mg
貯蔵方法：室温
有効期間：製造から2年
PN5 旧容器記号 C C3 4
EDTA-2Na入り (真空採血量5mL)
内容：EDTA-2Na 7.5mg
貯蔵方法：室温
有効期間：製造から2年
A00 旧容器記号 X
ポリスピッツ
貯蔵方法：室温
supplementary information
[0G06 2]
[B687 8]
[792803]
[7928]
アルドステロン〔CLEIA〕/レニン濃度比
[0E49 9]
[B691 3]
[792903]
[7929]
アルドステロン〔CLEIA〕/レニン活性比 基準値
| アルドステロン〔CLEIA〕 (pg/mL) | 4.0～82.1 |
|---|---|
| レニン濃度 (ARC)〔CLEIA〕 (pg/mL) | 2.21～39.5 |
| レニン活性 (PRA)〔EIA〕 (ng/mL/hr) | 臥位 0.2～2.3 座位 0.2～3.9 立位 0.2～4.1 |
| アルドステロン〔CLEIA〕/レニン濃度比 | 20未満 |
| アルドステロン〔CLEIA〕/レニン活性比 | 100未満 |
※陽性判定は、濃度比≧40または活性比≧200かつ血漿アルドステロン濃度≧60 pg/mLです。
ただし、「ARR境界域」の濃度比20～40未満または活性比100～200未満かつ血漿アルドステロン濃度≧60 pg/mLの場合には、
暫定的に陽性とされます。
※暫定的に陽性の場合、患者ニーズと臨床所見、特に低カリウム血症や副腎腫瘍の有無、 年齢などを考慮して、機能確認検査実施の要否を個別に検討する、とされています。
