Aldosterone 〔CLEIA〕/renin activity ratio

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Aldosterone 〔CLEIA〕/renin activity ratio

Laboratory：Akiruno

○Aldosterone 〔CLEIA〕/renin activity ratio

CODE：00E49 3

TEST NAME SPECIMEN
REQUIREMENT
（ｍL） CONTAINER CAP COLOR STORE
TEMPERATURE
(STABILITY) TURNAROUND
TIME (DAY) METHODOLOGY REFERENCE RANGE
(UNIT)
Aldosterone 〔CLEIA〕/renin activity ratio

Plasma
1.2
PN2,PN5
↓
A00
（14 days）
3-5 Aldosterone: CLEIA Renin activity: EIA See below

COMMENT

The standard value is the cut-off value according to the "Primary Aldosteronism Treatment Guidelines 2021" of the Japan Endocrine Society.
"4609 5: Aldosterone [CLEIA]", "00G06 2: Aldosterone [CLEIA]/renin concentration ratio", "00E49 9: Aldosterone [CLEIA]/renin activity ratio" cannot be requested at the same time.
"08029 1: Renin activity (PRA) [EIA]" and "00E49 9: Aldosterone [CLEIA]/renin activity ratio" cannot be requested at the same time.
●Notes on aldosterone [CLEIA]/renin activity ratio
・It is stated that blood collection is preferred to be conducted in the early morning, fasted, and in a resting position, but that screening can be conducted in a sitting position at any time.
・When stored refrigerated, an increase in renin concentration will be observed.
Collect blood into the container shown below, mix well, and separate the plasma. Be sure to store plasma frozen.

CONTAINER

PN2 旧容器記号 C C3 4

EDTA-2Na入り (真空採血量2mL)

内容：EDTA-2Na　3.0mg
貯蔵方法：室温
有効期間：製造から2年

PN5 旧容器記号 C C3 4

EDTA-2Na入り (真空採血量5mL)

内容：EDTA-2Na　7.5mg
貯蔵方法：室温
有効期間：製造から2年

A00 旧容器記号 X

ポリスピッツ

貯蔵方法：室温

supplementary information

[00G06 8] [0G06 2] [B687 8] [792803] [7928] アルドステロン〔CLEIA〕/レニン濃度比
[00E49 3] [0E49 9] [B691 3] [792903] [7929] アルドステロン〔CLEIA〕/レニン活性比基準値

アルドステロン〔CLEIA〕 (pg/mL)	4.0～82.1
レニン濃度 (ARC)〔CLEIA〕 (pg/mL)	2.21～39.5
レニン活性 (PRA)〔EIA〕 (ng/mL/hr)	臥位　0.2～2.3 座位　0.2～3.9 立位　0.2～4.1
アルドステロン〔CLEIA〕/レニン濃度比	20未満
アルドステロン〔CLEIA〕/レニン活性比	100未満

※陽性判定は、濃度比≧40または活性比≧200かつ血漿アルドステロン濃度≧60 pg/mLです。
ただし、「ARR境界域」の濃度比20～40未満または活性比100～200未満かつ血漿アルドステロン濃度≧60 pg/mLの場合には、暫定的に陽性とされます。

※暫定的に陽性の場合、患者ニーズと臨床所見、特に低カリウム血症や副腎腫瘍の有無、年齢などを考慮して、機能確認検査実施の要否を個別に検討する、とされています。

Aldosterone [CLEIA] (pg/mL)	4.0-82.1
Renin concentration (ARC) [CLEIA] (pg/mL)	2.21-39.5
Renin activity (PRA) [EIA] (ng/mL/hr)	Recumbent position 0.2-2.3 Sitting position 0.2-3.9 Standing position 0.2-4.1
Aldosterone [CLEIA]/renin concentration ratio	Less than 20
Aldosterone [CLEIA]/renin activity ratio	Less than 100

TEST DIRECTORY